Molecular Regulation
Laboratory of Molecular Genetics

Vinella, D., Cashel, M., and D'Ari, R., Selected amplification of the cell division genes ftsQ-ftsA-ftsZ in Escherichia coli. Genetics. 156:1483-1492, 2000.

Cashel, M. The stringent response. In Encyclopedia of Microbiology, 2nd edition. Joshua Lederberg (ed). Academic Press, San Diego CA. 2000.

Hou. Z., Cashel, M., Fromm, H.J., and Honzatko, R.B., Effectors of the stringent response target the active site of Escherichia coli adenylosuccinate synthetase. J. Biol. Chem. 274: 17505-17510, 1999.

Wrobel, B., Murphy, H., Cashel, M., and Wegrzyn, G., Guanosine tetraphosphate (ppGpp)-mediated inhibition of the activity of the bacteriophage lambda PR promoter in Escherichia coli. Mol.Gen. Genet. 257:490-495, 1998.

Kuroda, A., Murphy, H., Cashel, M., and Kornberg, A. Guanosine tetra- and pentaphosphate promoter accumulation of inorganic polyphosphate in Escherichia coli. J. Biol. Chem. 272:21240-21243, 1997.

Vinella, D., Gagny, B., Joseleau-Petit, D., Dari R., and Cashel, M. Mecillinam Resistance in Escherichia coli is conferred by loss of a second activity of the aroK protein. J. Bacteriol. 178:3818- 3826, 1996.

Gentry, D.M. and Cashel, M. Mutational analysis of the Escherichia coli spoT gene identifies distinct but overlapping regions involved in ppGpp synthesis and degradation. Molec. Microb. 19:1373-1384, 1996.

Mechold, U., Cashel, M., Steiner, K., Gentry, D.R., and Malke, H.A. A functional analysis of rel-se, a relA/spoT gene homolog from Streptococcus equisimilis. J. Bacteriol. 178:1401-1411, 1996.

Hernandez, V.J., Hsu, L.M., and Cashel, M. Conserved region 3 of Escherichia coli s70 is inplicated in the process of abortive transcription. J. Biol. Chem. 271:18775-18779, 1996.

Cashel, M., Gentry, D.M., Hernandez, V.J., and Vinella, D. The stringent response. In Escherichia coli and Salmonella typhimurium Cellular and Molecular Biology. (F. C. Neidhardt, Ed. in Chief). ASM Press, Washington D.C. vol 1:1458-1496, 1996.

Hernandez, V.J. and Cashel, M. Changes in conserved region 3 of Escherichia coli s70 mediate ppGpp-dependent functions in vivo. J. Mol. Biol. 252:536-549, 1995.
Gentry, D.M. and Cashel, M. Cellular localization of SpoT protein. J. Bacteriol. 177:3890- 3893, 1995.

Gentry, D.M., Hernandez, V.J., Nguyen, L.H., Jensen, D.R., and Cashel, M. Synthesis of the stationary-phase sigma factor, sS, is positively regulated by ppGpp. J. Bacteriol. 75:7982-7989. 1993.

Cashel, M. Detection of (p)ppGpp accumulation patterns in Escherichia coli mutants. In Methods in Molecular Genetics Vol. 3 Molecular Microbiology Techniques Part A (K.W. Adolph, Ed.) Academic Press pp 341-356, 1993.

Gentry, D., Bengra, C., Ikehara, K., and Cashel, M. Guanylate kinse of Escherichia coli K- 12. J. Biol. Chem. 269:14316-14321, 1993.

Svitil, A.L., Cashel, M., and Zyskind, J.W. Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation stress in Escherichia coli. J. Biol. Chem. 268:2307-2311, 1993.

Jones. P.G., Cashel, M., Glaser, G., and Neidhardt, F.C. Function of a relaxed-like state following temperature downshifts in Escherichia coli. J. Bacteriol. 174:3903-3914, 1992.

Kalman, M., Murphy, H., and Cashel, M. The nucleotide sequence of recG, the distal spo operon gene in Escherichia coli K-12. Gene 110:95-99, 1992.

Kalman, M., Murphy, H., and Cashel, M. rhlB a new E. coli K-12 gene with a RNA helicas- like protein sequence motif, one of at least five such possible genes in a prokaryote. New Biol. 3:886-895, 1991.

Gentry, D., Xiao, H., Burgess, R., and Cashel, M. The omega subunit of Escherichia coli is not required for stringent RNA control in vivo. J. Bacteriol. 173:3901-3903, 1991.

Xiao, H., Kalman, M., Ikehara, K., Zemel, S., Glaser, G., and Cashel, M. Residual guanosine 3',5'-bispyrophosphate (ppGpp) synthetic activity of relA null mutants can be eliminated by spoT null mutations. J. Biol. Chem. 266:5980-5990, 1991.

Schreiber, G., Metzger, S., Aizenman, E., Roza, S., Cashel, M., and Glaser, G. Overexpression of the relA gene in Escherichia coli. J. Biol. Chem. 266:3760-3767, 1991.

Kalman, M., Gentry, D.R., and Cashel, M. Characterization of the Escherichia coli K-12 gltS glutamate permease gene. Mol. Gen. Genetics 225: 379-386, 1991.


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